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Anesth Analg 1987; 66:615-618
© 1987 International Anesthesia Research Society
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Postoperative Analgesia Induced by Subarachnoid Lidocaine plus Calcitonin

Fernando S. Miralles, MD, Francisco Lopez-Soriano, MD, Margarita M. Puig, MD, Domingo Perez, PhD, and Felix Lopez-Rodriguez, MD

Received from the Department of Anesthesiology CSV Arrixaca Hospital, Murcia, Spain, and the Department of Anesthesiology, New York University Medical Center, New York, New York. Address correspondence to Dr. Puig, Department of Anesthesiology, New York University Medical Center, 550 First Avenue, New York, NY 10016.

Abstract

A randomized double-blind study tested the analgesic effects of subarachnoid administration of salmon calcitonin (sCT) in acute postoperative pain. Sixty patients were grouped according to type of surgery (intraabdominal, extraabdominal, and lower extremities), subdivided into those given subarachnoid lidocaine 1 mg/kg plus sCT (100 IU) or lidocaine plus saline. Pain was evaluated by a descriptive scale 3, 6, 12, 24, 48, and 72 hr after surgery, as well as by the frequency of the patients' requests for postoperative analgesics. In all instances, the sCT-treated patients had significantly less postoperative pain. Similarly, the requests for analgesics was significantly lower or absent in the sCT-treated group. Minor side effects such as nausea and vomiting, abdominal pain, and "nervousness" were observed in a small number of sCT-treated patients. In our series of 30 patients, subarachnoid administration of sCT was an effective analgesic with minimal side effects. Its safety remains to be proved by further studies.

Key Words: PAIN—postoperative. • PHARMACOLOGY—calcitonin.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.