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Anesth Analg 1987; 66:625-628
© 1987 International Anesthesia Research Society
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Midazolam as an Induction Agent in Children

A Pharmacokinetic and Clinical Study

Markku Salonen, MD, Jussi Kanto, MD, Eila lisalo, MD, and Jaakko-Juhani Himberg, MD, PhD

Received from the Department of Anesthesiology and Pharmacology, University of Turku, Turku, Finland and from the Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland. Address correspondence to Dr. Salonen, Fellow in Anesthesiology, Turku University Central Hospital, Kiinamyllynkatu 4–8, 20520 Turku 52, Finland.

Abstract

The pharmacokinetics of midazolam was studied in 21 children undergoing elective surgery at five different dose levels for induction of general anesthesia and were compared with a control group (n = 6) given thiopental, 5 mg/kg. The clearance of midazolam was found to be dose-related. The elimination half-life varied from 0.79 to 2.83 hr, which is shorter than in adult patients. Even a dose of 0.6 mg/kg midazolam was found to be unreliable as an agent for induction of anesthesia. Compared with thiopental 5 mg/kg, significantly longer times of onset to closing of the eyes (P<0.01) and the disappearance of eyelid reflex (P<0.01) were seen with midazolam.

Key Words: HYPNOTICS, BENZODIAZEPINES—midazolam. • INDUCTION, ANESTHESIA—midazolam. • ANESTHETICS, INTRAVENOUS—benzodiazepines. • ANESTHESIA—pediatric.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.