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Received from the Department of Anesthesia, University of California, San Francisco, California. Address correspondence to Dr. Eger, Department of Anesthesia, University of California, Room 1386 HSE, Third and Parnassus Avenues, San Francisco, CA 94143–0542.
Abstract
The purpose of this study was to determine partition coefficients for a new rapid-acting inhaled anesthetic, sevoflurane. Blood samples were taken from 19 ASA physical status I-III patients ranging in age from 21 to 77 yr who were scheduled for elective surgery. At 37°C, we found a blood/gas partition coefficient of 0.686 ± 0.047 (mean ± SD), a saline/gas partition coefficient of 0.370 ± 0.016; and an oil/gas partition coefficient of 47.2 ± 2.7. These values are consistent with the clinical observation that sevoflurane is a potent inhaled anesthetic that produces a rapid induction of and recovery from anesthesia.
Key Words: ANESTHETICS, VOLATILE—sevoflurane. • SOLUBILITY—sevoflurane.
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