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Anesth Analg 1987; 66:719-722
© 1987 International Anesthesia Research Society
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Peripheral Neurotoxicity of 2-Chloroprocaine and Bisulfite in the Cat

Douglas J. Ford, PhD, and P. Prithvi Raj, MD

Received from the Department of Anesthesia, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Abstract

The responses of peripheral nerves less than 6 hr after and 2 weeks after exposure to 2-chloroprotaine (2-CP) and bi sulfite (BS) were studied in cats using electro physiologic techniques and by light and electron microscopy. Three percent 2-CP with 0.07% or 0.2% BS was not toxic to peripheral nerves. Three percent 2-CP with 1.2% BS and 1.2% BS (pH 2.8) alone had an acute effect on the peripheral nerves but no chronic effect. Ten percent BS (pH2.8) caused Wallerian degeneration. However, at pH 4.8, no chronic toxicity was observed. Using conductivity measurements, it was shown that 2-CP and BS, when mixed, form an ion pair in solution that lowers the effective concentration of BS.

Key Words: ANESTHETICS, LOCAL—2-chloroprocaine • TOXICITY—bisulfite, 2-chloroprocaine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.