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Anesth Analg 1987; 66:746-750
© 1987 International Anesthesia Research Society
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Changes in Serum Glucose and Serum Growth Hormone Levels during Pituitary Surgery

Kazuo Maruyama, MD, Mannosuke Muneyuki, MD, Tadashi Kojima, MD, Hiroshi Hashimoto, MD, Yumiko Oi, MD, Masahiro Okuda, MD, Takaaki Kurioka, MD, Yoshihisa Fujita, MD, and Kunihiko Konishi, MD

Received from the Departments of Anesthesiology and Neurosurgery, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan.

Abstract

During trans sphenoidal surgery, serum growth hormone (GH) and serum glucose levels were measured in five ac-romegalic patients with diabetes or glucose intolerance, three acromegalic patients without diabetes or glucose intolerance, and six patients with prolactinoma. Preoperative steroid administration produced a significant increase in serum glucose level in acromegalic patients with diabetes or glucose intolerance, whereas in the other two groups no significant change in serum glucose level was found. After surgery started, there was a statistically significant increase in serum glucose level above baseline levels in all three groups. Serum GH levels decreased after commencement of surgery in acromegalic patients, and tumor manipulation did not produce a statistically significant increase in serum GH levels. Simultaneous increases in serum glucose and serum GH levels upon tumor manipulation did not occur in any group. We conclude that preoperative steroid administration in patients with high serum levels of GH in association with diabetes or glucose intolerance increases serum glucose levels, and that, after commencement of surgery, GH has only a minor role in the changes of serum glucose levels.

Key Words: ANESTHESIA—neurosurgery • SURGERY—neurologic • HORMONES—growth






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.