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Anesth Analg 1987; 66:769-773
© 1987 International Anesthesia Research Society
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Toxicity of Sevoflurane in Rats

David P. Strum, MD, Edmond I. Eger, II, MD, Brynte H. Johnson, AB, Eugene P. Steffey, VMD, PhD, and Linda D. Ferrell, MD

Received from the Departments of Anesthesia and Pathology, University of California, San Francisco, California.

Abstract

Sevoflurane, an experimental potent volatile anesthetic with a low blood/gas partition coefficient, degrades in the presence of soda lime to products the toxicity of which is unknown. We tested whether toxic products were produced by the passage of sevoflurane through soda lime, and a comparison was made of the toxicity of sevoflurane passed through soda lime with the toxicity of other potent volatile anesthetics in current clinical use. Halothane, isoflurane, sevoflurane (all in 1-MAC concentrations), or no anesthetic (control) were passed through soda lime for 4 hr with 12, 14, or 300% oxygen to groups of rats with hepatic microsomal enzyme induction. Separate groups of 12–13 rats were given 1 MAC of sevoflurane that had not passed through soda lime and either 14 or 100% oxygen. Sevoflurane was no more toxic than isoflurane and both of these anesthetics were less toxic than halothane. Soda lime was not a factor in any toxicity produced. Hepatic injury with all agents varied inversely with the oxygen concentration administered during anesthesia.

Key Words: ANESTHETICS, VOLATILE—halothane, isoflurane, sevoflurane • TOXICITY—sevoflurane • LIVER—hepatotoxicity




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T. Nishiyama, T. Fujimoto, and K. Hanaoka
A Comparison of Liver Function After Hepatectomy in Cirrhotic Patients Between Sevoflurane and Isoflurane in Anesthesia with Nitrous Oxide and Epidural Block
Anesth. Analg., April 1, 2004; 98(4): 990 - 993.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.