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Anesth Analg 1987; 66:843-846
© 1987 International Anesthesia Research Society
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Influence of Age on Vascular Absorption of Lidocaine from the Epidural Space

Brendan T. Finucane, MD, William D. Hammonds, MD, and Michael B. Welch, MD

Received from Grady Memorial Hospital and Emory University Hospital at Emory University, Atlanta, Georgia.

Abstract

The purposes of this study were to evaluate the effect of age on the vascular absorption of local anesthetics during epidural anesthesia and to corroborate the clinical observations of other investigators with respect to age. Using the arbitrary definition of significance (P < 0.05), the maximum serum levels of lidocaine (Csmax) did not differ significantly with age, however, P values were equal to 0.06. Furthermore, the time to Csmax was significantly faster in elderly patients (P < 0.00001). In conclusion, the mass of local anesthetic solution should be reduced in elderly patients undergoing epidural anesthesia because there is a greater segmental spread, and serum levels of local anesthetics are increased.

Key Words: ANESTHETIC TECHNIQUES—epidural • AGE—epidural anesthesia • PHARMACOKINET—ICS-epidural lidocaine




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 Anesth. Analg.Home page
W. A. Visser, R. A. Lee, and M. J. M. Gielen
Factors Affecting the Distribution of Neural Blockade by Local Anesthetics in Epidural Anesthesia and a Comparison of Lumbar Versus Thoracic Epidural Anesthesia
Anesth. Analg., August 1, 2008; 107(2): 708 - 721.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1987 by the International Anesthesia Research Society.