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Awakening Concentrations of Isoflurane Are Not Affected by Analgesic Doses of Morphine

Received from the Departments of Anesthesia, University of Pennsylvania and Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania.

Abstract

A randomized, double-blind study was performed to determine how morphine 0.1 mg/kg IV, or placebo administered 80 ± 11 ( ± SE) minutes before the end of surgery affect recovery from isoflurane/oxygen anesthesia. End-tidal isoflurane remainedconstant at 1.10 ± 0.02% ( ± SE) in both groups intraoperatively, and no other anesthetics were given after the administration of the morphine or placebo. Duration of anesthesia did not differ significantly between the morphine (172 ± 7 minutes) and placebo (163 ± 18 minutes) groups. Times from discontinuation of isoflurane until eye-opening in response to verbal command were similar in the morphine (19 ± 2 minutes) and placebo (22 ± 3 minutes) groups. At the time of eye-opening, end-tidal isoflurane concentrations did not differ between subjects receiving morphine (0.20 ± 0.02%) and placebo (0.18 ± 0.01%). It is concluded that the awakening concentration (MAC-awake) during recovery from isoflurane anesthesia is approximately 0.19% and is not affected by analgesic doses of morphine.

Key Words: ANALGESICS, NARCOTIC—morphine • ANESTHETICS, VOLATILE—isoflurane • POTENCY, ANESTHETIC—MAC • POTENCY, ANESTHETIC—MAC-awake

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999