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Anesth Analg 1988; 67:61-63
© 1988 International Anesthesia Research Society
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Long-Term Bupivacaine Infusion Does Not Alter the Acute Seizure Threshold to Bupivacaine in Rats

B. Skeie, MD, N. K. Meidell, MD, and P. A. Steen, MD

Received from the Department of Anesthesiology and the Institute for Experimental Research, Ullevaal Hospital, University of Oslo, Oslo, Norway.

Abstract

Rats were given a continuous subcutaneous infusion of either bupivacaine (n = 18) or placebo (n = 17) for 4 days. On the 5th day the acute seizure threshold to intravenous bupivacaine was determined in both groups. Blood and brain concentrations of bupivacaine at the onset of seizures showed no difference between the two groups, whereas the seizure dose was decreased in the bupivacaine group. The tachyphylaxis observed when bupivacaine is used for a regional nerve blockade does not seem to evolve for the central nervous system effects.

Key Words: ANESTHETICS, LOCAL—bupivacaine • PHARMACOLOGY—tachyphylaxis • TOXICITY—bupivacine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.