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Anesth Analg 1988; 67:69-70
© 1988 International Anesthesia Research Society
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Cimetidine Does Not Affect Plasma Cholinesterase Activity

J. Reddy Kambam, MD, and John J. Franks, MD

Received from the Department of Anesthesiology, Vanderbilt University Hospital, Nashville, Tennessee.

Abstract

Blood samples were drawn from 10 ASA physical status 1 and 2 patients before (baseline) and after the administration of cimetidine to determine the in vivo effect of cimetidine on plasma cholinesterase (PCHE) activity. The in vitro effects of cimetidine at different plasma concentrations were also studied using the same blood samples. PCHE activity in the baseline samples was 432 ± 4.6 (mean ± SEM) U/ml, the dibucaine number 82. Administration of oral cirnetidine (300 mg) the night before and 2 hours before surgery, failed to have any effect on PCHE activity (no in vivo effect). Plasma cholinesterase activity in the presence of cirnetidine in vitro at plasma concentrations of 1.5, 15, 150, and 1500 µg/ml was 428, 420, 397, and 177 U/ml, respectively. Thus, in vitro data showed that cimetidine at plasma concentrations (1.5 to 15 µg/ml) achieved with clinical doses also has no effect on PCHE activity.

Key Words: NEUROMUSCULAR RELAXANTS—succinylcholine • ENZYMES—pseudocholinesterase • HISTAMINE—cimetidine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.