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Anesth Analg 1988; 67:1166-1168
© 1988 International Anesthesia Research Society
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Hemodynamic Effects of Nifedipine in a Canine Model of Acid Aspiration

James K. Griffeth, MD, T. James Gallagher, MD, and David L. Packer, MD

The Departments of Anesthesiology and Surgery, University of Florida College of Medicine, Gainesville, Florida.

Abstract

A solution of ethyl alcohol, polyethylglycol, and distilled water that did (n = 5) or did not (n = 5) contain 250 µg/kg of the calcium channel blacker, nifedipine, was infused into the right atrium in 10 healthy mongrel dogs. Hydrochloric acid (pH = 1.8), 2 ml/kg, was then instilled into both lungs of all dogs via the tracheal tube. Hemodynamic data were collected before and 10 minutes after nifedipine was infused and 10, 45, 90, and 180 minutes after acid was instilled into the lungs. Gas exchange, including PaO2 and venous admixture, did not differ between the two groups. However, after aspiration, oxygen delivery significantly improved in the dogs given nifedipine compared to oxygen delivery in those not treated with nifedipine. We conclude that, despite significant decreases in PaO2 and venous admixture, nifedipine can restore oxygen delivery back to normal levels.

Key Words: LUNG, ASPIRATION. • PHARMACOLOGY, calcium channel BLOCKERS—nifedipine.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.