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Anesth Analg 1988; 67:1174-1176
© 1988 International Anesthesia Research Society
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Minimum Alveolar Concentration of 1–653 and Isoflurane in Pigs

Definition of a Supramaximal Stimulus

Edmond I. Eger, II, MD, Brynte H. Johnson, ms, Richard B. Weiskopf, MD, Margot A. Holmes, BS, Nobuhiko Yasuda, MD, Alex Targ, BS, and Ira J. Rampil, MD

The Department of Anesthesia and the Cardiovascular Research Institute, University of California, San Francisco, California, 94143–0464.

Abstract

We determined the anesthetic potencies of a new fluorinated anesthetic, 1–653, and isoflurane in pigs as a preliminary to a study of the relative cardiovascular and electroencephalographic effects of these agents. Clamps were sequentially applied to the dew claw and/or tail of each animal to determine the minimum alveolar concentration (MAC) that suppressed movement in response to each of these stimuli. MAC obtained by clamping the tail (8.28 ± 1.34% [mean ± standard deviation] for 1–653 and 1.653 ± 0.36% for isoflurane) was more variable and lower than MAC obtained by clamping the dew claw (10.00 ± 0.94% for 1–653 and 2.04 ± 0.19% for isoflurane). We conclude that the type of stimulus applied affects the MAC value obtained for 1–653 and isoflurane. Clamping the tail is not a supramaximal stimulus in pigs; a greater stimulus is provided by clamping the dew claw.

Key Words: ANESTHETICS, VOLATILE—I-653, isoflurane. • POTENCY, ANESTHETIC—I-653, isoflurane.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.