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Anesth Analg 1988; 67:166-169
© 1988 International Anesthesia Research Society
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Reproductive and Teratogenic Effects of Sufentanil and Alfentanil in Sprague-Dawley Rats

Masahiko Fujinaga, MD, Richard I. Mazze, D, Ethan C. Jackson, and Jeffrey M. Baden, MD

Department of Anesthesia, Stanford University School of Medicine, Stanford, California, and the Anesthesiology Service, Palo Alto Veterans Administration Medical Center, Palo Alto, California.

Abstract

The reproductive and teratogenic effects of sufentanil and alfentanil were studied in a total of 168 Sprague-Dawley rats in two separate experiments. Either sufentanil (10, 50, or 100 µg·kg–1·day–1) or alfentanil (8 mg·kg–1 ·day–1) were administered continuously from day 5 through day 20 of pregnancy using subcutaneously implanted osmotic minipumps. Cesarcan sections were performed on day20 of pregnancy, reproductive indexes were determined, and the 1484 fetuses were examined for external, visceral, and skeletal abnormalities. No significant adverse reproductive or teratogenic effects were observed witheither narcotic.

Key Words: NARCOTICS—sufentanil, alfentanil. • PREGNANCY, TERATOGENICITY—sufentanil, alfentanil. • TOXICITY, REPRODUCTIVE—sufentanil, alfentanil.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.