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Anesth Analg 1988; 67:233-239
© 1988 International Anesthesia Research Society
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Comparison of Buprenorphine with Morphine in the Treatment of Postoperative Pain in Children

Eeva-Liisa Maunuksela, MD, Reijo Korpela, MD, and Klaus T. Olkkola, MD

the Children's Hospital and the Department of Clinical Pharmacology, University of Helsinki, Finland.

Abstract

The safety and efficacy of buprenorphine and morphine as postoperative analgesicsfor children were compared in 60 boys and girls 4 to 14 years old having elective orthopedic operations on upper or lower extremities. The drugs were given in a double-blind manner initially intravenously and thereafter by sublingual buprenorphine or intramuscular morphine administered as required to relieve pain until the third postoperative morning. The IV dose needed to achieve complete initial analgesia was 5.2 ± 2.8 µg/kg buprenorphine and 166 ± 100 µg/kg morphine. The duration of effect was significantly longer with buprenorphine than with morphine, 248 ± 314 and 114 ± 109 minutes, respectively (P = 0.03). The most common side effects were nausea and vomiting (28 and 16%) and urinary retention (21 and 19%) in the buprenorphine and morphine groups, respectively. Analgesia with sublingual buprenorphine was as effective and reliable as with intramuscular morphine but a longer duration of action could not be demonstrated.

Key Words: ANALGESICS—buprenorphine, morphine • PAIN, POSTOPERATIVE—pediatric • ANESTHESIA—pediatric




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.