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Anesth Analg 1988; 67:268-271
© 1988 International Anesthesia Research Society
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Pharmacokinetics of Sufentanil in Adolescent Patients Renal Failure

Peter J. Davis, MD, Richard L. Stiller, PhD, D. Ryan Cook, MD, Barbara W. Brandom, MD, and Karen A. Davin-Robinson, CRNA

Departments of Anesthesiology, Psychiatry, and Pharmacology, Children's Hospital of Pittsburgh, the Western Psychiatric Institute and Clinic, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Abstract

The role of the kidney in sufentanil elimination or metabolism has not been defined. The effects of chronic renal failure (CRF) on the pharmacokinetic profile of sufentanil were evaluated in six adolescent patients undergoing renal transplantation, and these findings were compared with data from age-matched control patients with normal renal function who were undergoing other surgical procedures. Patients with CRF weighed significantly less than did the control patients (28.7 ± 5.7 vs 44.7 ± 12.9 kg [mean ± SD]). Although there was no statistical difference in the rate of clearance orapparent volume of distribution and half-life between the two groups, clearance and half-life were more variable among patients with CRF. In these patients, therefore, sufentanil dose must be carefully administered based on responses elicited in individual patients.

Key Words: ANALGESICS—sufentanil • PHARMACOKINETICS—sufentanil • KIDNEY, RENAL FAILURE—sufentanil






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.