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Anesth Analg 1988; 67:303-306
© 1988 International Anesthesia Research Society
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Clinical Pharmacology of Doxacurium Chloride (BW A938U) in Children

Joel B. Sarner, MD, Barbara W. Brandom, MD, D. Ryan Cook, MD, Mai-Li Dong, MD, Michael C. Horn, MD, Susan K. Woelfel, MD, Peter J. Davis, MD, G. David Rudd, MS, Vicki J. Foster, MSPH, and Barbara F. McNulty, MPH

Received from the Departments of Anesthesiology, Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania, and the Department of Clinical Neurosciences, Clinical Research, Burroughs Wellcome Co., Research Triangle Park, North Carolina.

Abstract

The neuromuscular effects of doxacurium were studied in 26 children during halothane-nitrous oxide-oxygen anesthesia. Neuromuscular blockade was measured using electromyography activity of the adductor pollicis muscle after supra maximal stimulation of the ulnar nerve at 2 Hz for 2seconds at 10-second intervals. To estimate the cumulative dose-response relation, nine patientsreceived incremental doses of doxacurium (2.5–10 µg/kg); nine patients received 27.5 µg/kg (the estimated ED95); eight patients received 50µg/kg (1.8 x ED95). The ED25, EDM, ED75' and ED95 (estimated from linear regression plots of log dose vs probit of effect) were 11.5, 14.8, 19.0, and 27.3 fJ-g/kg, respectively. Clinical duration (T25) was 27.8 ± 10.3 (mean ± SD) minutes at 1 x ED95 and 50.6 ± 15.6 minutes at 1.8 x ED95. Timeto recovery of the train-of-four ratio to 0.75 was 63.1 ± 32.9 minutes at 1 x ED95 and 108,5 ± 25.7 minutes at 1.8 x ED95. There were no significant changes in heart rate or mean arterial pressure after bolus administration of any dose ofdoxacurium.

Key Words: NEUROMUSCULAR RELAXANTS—doxacurium






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.