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Anesth Analg 1988; 67:324-328
© 1988 International Anesthesia Research Society
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A Double-Blind Study of the Respiratory Effects of Nalbuphine Hydrochloride in Spontaneously Breathing Anesthetized Patients

Stephen A. O'Connor, BSc, MSc, PhD, and David J. Wilkinson, MB, BS, FFARCS

Received from the Departments of Medical Electronics and Anaesthesia, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, United Kingdom.

Abstract

Nalbuphine hydrochloride 0.2 mg/kg was compared with meperidine 0.5 mg/kg in a double-blind study in 20 patients undergoing elective inguinal hernia repair while breathing spontaneously under general anesthesia. The respiratory effects of the two drugs studied were continuously andaccurately recorded with a wet wedge spirometer through out the procedure. The acute respiratoryeffects of these analgesic drugs could therefore be assessed. The measurements recorded before any surgical stimulation showed that both nalbuphine and meperidine produce a similar degree of respiratory depression. These results are at variance with earlier studies that drew conclusions from measurements that were neither continuous nor accurate. Nalbuphine was found to be a satisfactory analgesic adjuvant in this anesthetic technique.

Key Words: ANALGESICS—meperidine, nalbuphine






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.