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Anesth Analg 1988; 67:342-345
© 1988 International Anesthesia Research Society
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Midazolam-Thiopental Anesthetic Interaction in Patients

Mark Tverskoy, MD, PhD, Grigory Fleyshman, MD, Edwin L. Bradley, Jr, PhD, and Igor Kissin, MD, PhD

Received from the Department of Anesthesiology, Rebecca Sieff Government Hospital, Safed, Israel, and the Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama.

Abstract

The effect of thiopental on the induction dose-response curve for midazolam was studied innonpremedicated ASA physical status I and II patients. As an endpoint of anesthesia, ability to open eyes on command was used. Dose-response curves for thiopental, midazolam, and their combination were determined with a probit procedure and compared with an isobolographic analysis. Interaction between midazolam and thiopental was found to be synergistic (supraadditive). The degree of midazolam-thiopental anesthetic synergism in surgical patients was close to that reported previously in rats with loss of the righting reflex as an index of anesthesia.

Key Words: ANESTHETIC, INTRAVENOUS—midazolam, thiopental • INTERACTIONS, DRUGS—barbiturates, benzodiazepines




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.