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Anesth Analg 1988; 67:346-348
© 1988 International Anesthesia Research Society
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Thiopental Does Not Alter Ca2+ Uptake by Cardiac Sarcoplasmic Reticulum

Thomas J.J. Blanck, MD, PhD, and Robert L. Stevenson, MD

Received from the Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

Abstract

The effect of thiopental on Ca2+ uptake by cardiac sarcoplasmic reticulum (SR) isolated from the rabbit was examined to clarify the role of the sarcoplasmic reticulum in the negative inotropic action of thiopental, Thiopental, from 0 to 378 µM, did not alter the rate of Ca2+ uptake by the SR, We also compared the ATP dependence of Ca2+ uptake in the presence and absence of 284 µM thiopental. The Km for ATP and the Vmax of Ca+ uptake were unaffected by thiopental. It is concluded that thiopental does not alterCa2+ uptake by the SR and that the negative inotropic effects of thiopental occur at other sites in the myocardial cell.

Key Words: ANESTHETICS, INTRAVENOUS—thiopental • HEART, MYOCARDIAL FUNCTION—Ca2+ uptake • IONS—calcium




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A. Descorps-Declere, M. P. Sauviat, K. Samii, and Y. Lecarpentier
Mechanical and electrophysiological effects of thiopental on rat cardiac left ventricular papillary muscle
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[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.