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Anesth Analg 1988; 67:363-369
© 1988 International Anesthesia Research Society
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Effects of Continuous Arteriovenous Hemofiltration on Cardiopulmonary Abnormalities during Anesthesia for Orthotopic Liver Transplantation

Kenneth J. Tuman, MD, FCCP, Bruce D. Spiess, MD, Robert J. McCarthy, PharmD, William G. Logas, DO, James W. Williams, MD, and Howard N. Sankary, MD

Received from the Departments of Anesthesiology and Surgery, Rush Presbyterian-St. Luke's Medical Center, 1753 West Congress Parkway, Chicago, Illinois.

Abstract

Orthotopic liver transplantation (OUT) often involves large blood loss and replacement, aswell as administration of large amounts of blood products to correct coagulation defects. Renal free water excretion is often impaired in end-stage liver disease and not responsive to routine diuretic therapy, predisposing these patients to accumulation of extravascular lung water. The effects of the intraoperatives use of continuous arteriovenous hemofiltration (CAVH) on cardiopulmonary and oxygen transport variables were studied in ten patients during and 24 hours after OLT. CAVH prevented increases in pulmonary shunt fraction while decreasing PEEP and FIO2 requirements. Pulmonary compliance was significantly higher after operation in patients receivingCAVH. Before surgical dissection, hemodynamic effects of CAVH were minimal. Postoperatively, patients having CAVH had lower cardiac filling pressures and more normal systemic vascular resistance than did patients not having CAVH. These data suggest that CAVH may be a useful intraoperative technique for patients with impaired renal function undergoing liver transplantation.

Key Words: LIVER—transplantation • ANESTHETIC TECHNIQUES—liver transplantation




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.