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Cimetidine Does Not Inhibit Plasma Cholinesterase Activity

Received from the Departments of Anesthesiology, Children's Hospital of Pittsburgh, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Abstract

Cimetidine increases the duration of action of Succinylcholine several-fold by an unknown mechanism. The hydrolysis rate of succinylcholine by human plasma was measured with a modified spectrophotometric assay. At a concentration of 1–50 µg/ml cimetidine did not inhibit the hydrolysis of succinylcholine. It is concluded that cimetidine may have an effect at the neuromuscularjunction but does not inhibit plasma cholinesterase.

Key Words: NEUROMUSCULAR RELAXANTS—succinylcholine • PHARMACOLOGY—cimetidine

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999