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Anesth Analg 1988; 67:453-456
© 1988 International Anesthesia Research Society
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The Effect of General and Regional Anesthesia on Oxygen-Dependent Microbicidal Mechanisms of Polymorphonuclear Leukocytes in Children

Paolo Busoni, MD, Armando Sarti, MD, Maurizio De Martino, MD, Elisa Graziani, and Salvatore Santoro, MD

The Department of Anesthesia and Intensive Care, the Department of Pediatrics, Division of Allergy and Clinical Immunology, and the Division of Pediatric Surgery, Ospedale Pediatrico "A. Meyer," Firenze, Italy.

Abstract

The microbicidal activity of polymorphonuciear leukocytes (PMNL) was investigated in two groups of children undergoing hernia repair surgery. Group 1, after short general halothane anesthesia, received caudal analgesia, whereas group 2 received halothane anesthesia alone. Both groups showed a decrease in singlet oxygen production as demonstrated using chemiluminescence method. However, 24 hours after the end of surgery singlet oxygen production was fully recovered in the caudal analgesia group (group 1), whereas in the general anesthesia group (group 2), production was still significantly (P < 0.01) depressed. It is concluded that halothane may be associated with PMNL impairment, perhaps in a time-dependent manner.

Key Words: BLOOD, LEUKOCYTES—bactericidal activity.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.