JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 1988; 67:534-538
© 1988 International Anesthesia Research Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koblin, D. D.
Right arrow Articles by Waskell, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koblin, D. D.
Right arrow Articles by Waskell, L.

I-653 Resists Degradation in Rats

Donald D. Koblin, PhD MD, Edmond I. Eger, II, MD, Brynte H. Johnson, MS, Krystyna Konopka, PhD MD, and Lucy Waskell, MD, PhD

Departments of Anesthesia, Veterans Administration Medical Center, and University of California, San Francisco, and the Liver Center, University of California, San Francisco, California.

Abstract

The ability of rats pretreated with phenobarbital to metabolize a new volatile anesthetic, 1–653, was compared with the metabolism of halothane, isoflurane, and methoxy-flurane. Each anesthetic was administered for 2 hours at 1.6 MAC (inspired). Control rats were given phenobarbital but not exposed to an anesthetic. In rats pretreated with phenobarbital and exposed to 1–653, fluoride ion concentrations in serum and excretion of fluoride ion and organic fluoride in the urine were almost indistinguishable from values measured in control rats. In contrast, rats pretreated with phenobarbital metabolized small but significant amounts of isoflurane. In rats pretreated with ethanol and exposed to 1–653, the %hour excretion of urinary organic fluoride was nearlyten times greater than that observed in control rats. Marked increases in organic fluoride (as high as 1000 times control values) and/or fluoride ion were found in serum and/or urine after anesthesia of phenobarbital-pretreated rats with halothane or methoxyflurane. The relative stability of 1–653 indicates that it may possess minimal toxic properties.

Key Words: ANESTHETICS, volatile—I-653 • BIOTRANSFORMATION (DRUGS)-I-653




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
C. F. Kong, S. T. H. Chew, and P. C. Ip-Yam
Intravenous opioids reduce airway irritation during induction of anaesthesia with desflurane in adults{dagger}
Br. J. Anaesth., September 1, 2000; 85(3): 364 - 367.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.