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Anesth Analg 1988; 67:671-676
© 1988 International Anesthesia Research Society
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Alterations in the Course of and Histopathologic Response to Influenza Virus Infections Produced by Enflurane, Halothane, and Diethyl Ether Anesthesia in Ferrets

Alan R. Tait, PhD, P. Mark Du Boulay, MB, BS, FFARCS, and Paul R. Knight, MD, PhD

Received from the Department of Anesthesiology, The University of Michigan Medical Center, Ann Arbor, Michigan.

Abstract

Alterations in the course of and histopathologic response to influenza viral infections by halothane, enflurane, and diethyl ether anesthesia were evaluated in ferrets. There were no significant differences in the incidence and duration of lethargy, pyrexia, rhinorrhea, or sneezing in infected animals given one of the three anesthetic agents under investigation, compared with those receiving no anesthesia. There were no differences in lung pathology in infected animals given one of the three anesthetic agents, or no anesthesia, though histopathologic changes in the nasal turbinates were significantly greater in ferrets given enflurane. This study suggests that general anesthesia administered to ferrets infected with influenza virus carries minimal morbidity, although enflurane anesthesia was found to produce greater histopathologic changes than the other agents.

Key Words: ANESTHETICS, VOLATILE—halothane, enflurane, diethyl ether • INFECTION—influenza






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.