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Anesth Analg 1988; 67:677-682
© 1988 International Anesthesia Research Society
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Neurologic Outcome in Aged Rats After Incomplete Cerebral Ischemia

Verna L. Baughman, MD, William E. Hoffman, PhD, Chinnamma Thomas, MD, David J. Miletich, PhD, and Ronald F. Albrecht, MD

Received from the Departments of Anesthesiology and Pathology, Michael Reese Hospital and Medical Center, Chicago, Illinois, and the Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

Abstract

The effect of age on outcome after induced cerebral ischemia was tested in rats. Cerebral ischemia was produced by unilateral carotid ligation and hemorrhagic hypotension to 30 mm Hg (moderate ischemia) or 25 mm Hg (severe ischemia) in young (6 month) and old (26–28 month) rats anesthetized with 1 MAC halothane. Young rats had significantly better neurologic outcomes than old rats after similar ischemic challenges. This advantage disappears, however, when the inspired oxygen tension is altered to produce similar Pao2 in both age groups during ischemia. Measures of regional CBF with radioactive microspheres showed a 70% decrease in cortical blood flow in the ischemic cerebral hemisphere in both young and old rats. Plasma glucose concentrations increased from 150 to 250 mg/100 mL during ischemia in both age groups. Histologically, the brains showed similar signs of focal ischemic damage in striatum, hippocampus, and cortex in young and old rats. These results indicate that when blood pressure and respiratory factors are controlled experimentally during ischemia, young and aged rats have similar neurologic outcomes after cerebral ischemia.

Key Words: BRAIN—blood flow • AGE—cerebral function




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1988 by the International Anesthesia Research Society.