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Sixty-Two Years Ago In

Anesthesia & Analgesia

Abstract

While Assistant Professor of Applied Physiology at Yale, Haggard never heard the word pharmacokinetics. He became, however, one of the first pharmacokineticists when he established the principles of the uptake, distribution, and elimination of inhalation anesthetics. Yes, John Snow in the 1840s and '50s was somewhat of a pharmacokineticist, but this paper by Haggard and preceding papers by him in the Journal of Biological Chemistry (1924;59:737–802) describe with exquisite accuracy and detail matters such as determinants of anesthetic tension, partial pressures and equilibrium, quantitative aspects of anesthetic uptake, concentrations of anesthetics in the brain, utility of carbon dioxide, and "de-etherization." It is a humbling but infinitely rewarding experience to read Haggard's papers, not just this and his 1924 articles, but also his 1940 editorial on "The place of the anesthetist in American Medicine" that appeared on page I of volume 1 of that new journal, Anesthesiology.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999