JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 1993; 76:107-112
© 1993 International Anesthesia Research Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hayashi, Y.
Right arrow Articles by Kuro, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayashi, Y.
Right arrow Articles by Kuro, M.

Quantitative Analysis of Pulmonary Clearance of Exogenous Dopamine after Cardiopulmonary Bypass in Humans

Yukio Hayashi, MD, Koji Sumikawa, MD, Atsushi Yamatodani, MD, Takahiko Kamibayashi, MD, Tadanori Mammoto, MD, and Masakazu Kuro, MD

Department of Anesthesiology, National Cardiovascular Center, 5–7-1 Fujishiro-dai, and the Department of Anesthesiology and Molecular Chemistry and Pharmacology, Osaka University Medical School, Yamadaoka 2–2, Suita Osaka 565, Japan

The contribution of the lung to the clearance of exogenous dopamine after cardiopulmonary bypass (CPB) was analyzed quantitatively in humans and compared with the contribution of the lung before CPB. The pulmonary and arterial plasma concentration of dopamine and the pulmonary plasma flow were measured simultaneously during infusion of dopamine. Contribution of the pulmonary circulation was defined as the ratio between clearance through the pulmonary circulation and the total plasma clearance of dopamine. The calculated contribution values after CPB were 12.0, 10.7, 11.4, 16.2, and 16.7% at the doses of 3.0, 4.0, 5.0, 6.0, and 7.0 µg·kg–1·min–1, respectively. Those values before CPB were 15.6% and 17.4% at the doses of 1.0 and 2.0 µg·kg–1·min–1, respectively. The comparison of the values before and after CPB did not achieve statistical significance. Furthermore, there were no significant correlations between the pulmonary clearance after CPB and mean pulmonary arterial pressure, pulmonary vascular resistance, or CPB time. The results suggest that the pulmonary clearance mechanism for dopamine after CPB is maintained as effectively as that before CPB and is not influenced by pulmonary hypertension or CPB time.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
F. Boer
Drug handling by the lungs
Br. J. Anaesth., July 1, 2003; 91(1): 50 - 60.
[Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1993 by the International Anesthesia Research Society.