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Distinctive Effects of Three Intravenous Anesthetics on the Inward Rectifier (I_K1) and the Delayed Rectifier (I_K) Potassium Currents in Myocardium

Implications for the Mechanism of Action

Departments of Anesthesiology and Pediatrics, University of California, Los Angeles

Abstract

The mechanism(s) of action of anesthetics on cell membrane ionic currents are not known. To investigate this further the effects of clinically relevant concentrations of ketamine, methohexital, and propofol on the delayed rectifier (I_K) and the inward rectifier (I_K1) currents of single dispersed guinea pig ventricular myocytes were studied. These voltage-gated currents are major components of cardiac cell electrophysiologic function regulating resting potential and repolarization. Each of the three anesthetics had a distinct spectrum of activity. Ketamine (10^–4M) decreased I_K1 (P < 0.05) but had no effect on I_K. Methohexital (10^–4M) had no significant effect on either current. Propofol (2.8 x 10^–5M) resulted in significant depression of I_K (P < 0.001) but had no effect on I_K1. These results suggest that these intravenous anesthetics may have more specific effects on sarcolemma than volatile anesthetics, whose effects may be more generalized membrane effects.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999