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Anesth Analg 1993; 76:45-49
© 1993 International Anesthesia Research Society
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Ketamine Infusion for Postoperative Analgesia in Asthmatics

A Comparison with Intermittent Meperidine

Salim M. Jahangir, FCPS (Anesth), F. Islam, FCPS (Obs/Gyn), and L. Aziz, MB BS

From the Departments of Anesthesiology and Obstetrics & Gynecology, Medical College Hospital, Mymensingh 2200, Bangladesh

Abstract

Narcotics commonly used for postoperative analgesia may release histamine and cause bronchospasm in asthmatics. Ketamine, on the other hand, provides analgesia and has the additional advantage of preventing and relieving bronchospasm. We therefore delivered subanesthetic doses of ketamine in combination with midazolam (5.88–6.42 µg·kg–1·min–1and 1.17--1.28 µg·kg–1·min–1, respectively), via an infusion for postoperative analgesia after elective abdominal hysterectomy in patients with asthma. Data were compared with those from a similar group of patients receiving conventional intramuscular meperidine. A significant degree and earlier onset of analgesia (P < 0.05) was achieved in the ketamine group. For other variables no significant difference was observed between the groups (P > 0.05). Ketamine-midazolam infusion can thus provide a safe alternative to the usual parenteral narcotic therapy in asthmatics, in terms of analgesia and patient acceptability.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1993 by the International Anesthesia Research Society.